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Article

Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome.

PloS one - 1 Jan 2016

Komuro Hazuki, Sato Naoko, Sasaki Ayaka, Suzuki Naoki, Kano Michiko, Tanaka Yukari, Yamaguchi-Kabata Yumi, Kanazawa Motoyori, Warita Hitoshi, Aoki Masashi, Fukudo Shin

Abstract excerpt

BACKGROUND: Corticotropin-releasing hormone (CRH) plays an important role in the pathophysiology of irritable bowel syndrome (IBS) and regulates the stress response through two CRH receptors (R1 and R2). Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS. However, the association between the CRHR2 gene and IBS was not investigated. We...

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Share to Case-Control Studies
Share to CRH gene
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Share to Polymorphism, Single Nucleotide
Share to Receptors, Corticotropin-Releasing Hormone
Share to Stress Responses and Cortisol
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Source

Open in PubMed Open full text

Identifiers

PMID: 26808377
DOI: 10.1371/journal.pone.0147817
PMCID: PMC4726564

Genes

CRHR2
CRH
CRHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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