Article
Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study.
World journal of gastroenterology - 7 Jun 2022
Berens Sabrina, Dong Yuanjun, Fritz Nikola, Walstab Jutta, D'Amato Mauro, Zheng Tenghao, Wahl Verena, Boekstegers Felix, Bermejo Justo Lorenzo, Martinez Cristina, Schmitteckert Stefanie, Clevers Egbert, Engel Felicitas, Gauss Annika, Herzog Wolfgang, Spiller Robin, Goebel-Stengel Miriam, Mönnikes Hubert, Andresen Viola, Thomas Frieling, Keller Jutta, Pehl Christian, Stein-Thöringer Christoph, Clarke Gerard, Dinan Timothy G, Quigley Eamonn M, Sayuk Gregory, Simrén Magnus, Tesarz Jonas, Rappold Gudrun, van Oudenhove Lukas, Schaefert Rainer, Niesler Beate
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNPs) of the serotonin type 3 receptor subunit (HTR3) genes have been associated with psychosomatic symptoms, but it is not clear whether these associations exist in irritable bowel syndrome (IBS). AIM: To assess the association of HTR3 polymorphisms with depressive, anxiety, and somatization symptoms in individuals with IBS. METHODS: In this retrospective study, 623...
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