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Article

Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response.

Psychoneuroendocrinology - 1 Nov 2016

Orand Alexa, Naliboff Bruce, Gadd Malin, Shih Wendy, Ju Tiffany, Presson Angela P, Mayer Emeran A, Chang Lin

Abstract excerpt

BACKGROUND: Corticotropin-releasing hormone receptor 1 (CRH-R1) in the amygdala and the stria terminalis plays an important role in the activation of central stress circuits. Genetic factors may contribute to the hyperresponsiveness of these circuits in irritable bowel syndrome (IBS). AIMS: To determine if CRH-R1 SNPs are associated with: (1) a diagnosis of IBS, (2) gastrointestinal (GI) symptoms, and (3)...

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Share to CRF Receptor, Type 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Irritable Bowel Syndrome

Share to Polymorphism, Single Nucleotide

Share to Receptors, Corticotropin-Releasing Hormone

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Source

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Identifiers

PMID: 27497153
DOI: 10.1016/j.psyneuen.2016.07.204
PMCID: PMC5048544

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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