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Article

Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.

PloS one - 1 Jan 2016

Sasaki Ayaka, Sato Naoko, Suzuki Naoki, Kano Michiko, Tanaka Yukari, Kanazawa Motoyori, Aoki Masashi, Fukudo Shin

Abstract excerpt

UNLABELLED: Irritable bowel syndrome (IBS) is a common functional disorder with distinct features of stress-related pathophysiology. A key mediator of the stress response is corticotropin-releasing hormone (CRH). Although some candidate genes have been identified in stress-related disorders, few studies have examined CRH-related gene polymorphisms. Therefore, we tested our hypothesis that single-nucleotide...

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Source

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Identifiers

PMID: 26882083
DOI: 10.1371/journal.pone.0149322
PMCID: PMC4755592

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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