Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic target function annotation of human transcription factors.

BMC biology - 10 Jan 2018

Li Yong Fuga, Altman Russ B

Abstract excerpt

BACKGROUND: Transcription factors (TFs), the key players in transcriptional regulation, have attracted great experimental attention, yet the functions of most human TFs remain poorly understood. Recent capabilities in genome-wide protein binding profiling have stimulated systematic studies of the hierarchical organization of human gene regulatory network and DNA-binding specificity of TFs, shedding light on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Gene Regulatory Networks
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29325558
DOI: 10.1186/s12915-017-0469-0
PMCID: PMC5795274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic target function annotation of human transcription factors.PMID 29325558Read ↗

A proteocistromic atlas of 216 human disease-relevant transcription factorsSemantic proximity Read ↗

BART: a transcription factor prediction tool with query gene sets or epigenomic profilesSemantic proximity Read ↗

Decoding transcriptional regulation via a human gene expression predictorSemantic proximity Read ↗

Towards a map of cis-regulatory sequences in the human genome.Semantic proximity Read ↗

Human transcriptional gene regulatory network compiled from 14 data resourcesSemantic proximity Read ↗

Architecture of the human regulatory network derived from ENCODE data.Semantic proximity Read ↗

Benchmark and integration of resources for the estimation of human transcription factor activitiesSemantic proximity Read ↗

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factorsSemantic proximity Read ↗

TF-Target Finder: An R Web Application Bridging Multiple Predictive Models for Decoding Transcription Factor-Target InteractionsSemantic proximity Read ↗

Inferring functions of coding and non-coding genes using epigenomic patterns and deciphering the effect of combinatorics of transcription factors binding at promotersSemantic proximity Read ↗

Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory dataSemantic proximity Read ↗

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.