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Orientation Regulation of Class-switch Recombination in Human B Cells

9 Sept 2024

Abstract excerpt

We developed a linear amplification-mediated high-throughput genome-wide translocation sequencing method to profile Ig class-switch recombination (CSR) in human B cells in an unbiased and quantitative manner. This enables us to characterize CSR junctions resulting from either deletional recombination or inversion for each Ig class/subclass. Our data showed that more than 90% of CSR junctions detected in...

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PMID: 39248600
DOI: 10.4049/jimmunol.2300842

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