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Article

Non-coding transcription and large-scale nuclear organisation of immunoglobulin recombination.

Current opinion in genetics & development - 1 Apr 2013

Stubbington Michael J T, Corcoran Anne E

Abstract excerpt

The enormous antigen receptor loci in lymphocytes are a paradigm of dynamic nuclear organisation, which is integral to their need to move extensively in 3D space to achieve distal gene synapse for V(D)J recombination and allelic exclusion. The loci undergo extensive 3D looping to bring distal genes together, controlled by several tissue-specific and ubiquitous factors, but how these factors achieve looping,...

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Share to Gene Rearrangement, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Receptors, Antigen, B-Cell

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Share to V(D)J Recombination

Source

Identifiers

PMID: 23434028
DOI: 10.1016/j.gde.2013.01.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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