Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease.

Current Alzheimer research - 1 Feb 2013

Evangelisti Elisa, Wright Daniel, Zampagni Mariagioia, Cascella Roberta, Fiorillo Claudia, Bagnoli Silvia, Relini Annalisa, Nichino Daniela, Scartabelli Tania, Nacmias Benedetta, Sorbi Sandro, Cecchi Cristina

Abstract excerpt

Several lines of evidence suggest that the initial events of amyloid-β peptide (Aβ) oligomerization and deposition in Alzheimer's disease (AD) involve the interaction of soluble oligomers with neuronal membranes. In this study, we show that Aβ42 oligomers are recruited to lipid rafts, which are ordered membrane microdomains rich in cholesterol and gangliosides, resulting in lipid peroxidation, Ca(2+)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Cerebral Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholera Toxin

Share to Gangliosidosis, GM1

Share to Lipid Peroxidation

Share to Membrane Microdomains

Share to Morpholines

Share to Presenilin-1

Source

Identifiers

PMID: 22950913
DOI: 10.2174/1567205011310020004

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease.PMID 22950913Read ↗

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane.Semantic proximity Read ↗

Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblasts.Semantic proximity Read ↗

[The role of cholesterol in Alzheimer's neuro-pathogenesis].Semantic proximity Read ↗

Iron associated lipid peroxidation in Alzheimer’s disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in miceSemantic proximity Read ↗

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Semantic proximity Read ↗

Membrane-Anchored Aβ Accelerates Amyloid Formation and Exacerbates Amyloid-Associated Toxicity in MiceSemantic proximity Read ↗

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.Semantic proximity Read ↗

The dysregulation of intracellular calcium in Alzheimer disease.Semantic proximity Read ↗

Intracellular calcium signalling in Alzheimer’s diseaseSemantic proximity Read ↗

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.Semantic proximity Read ↗

Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruptionSemantic proximity Read ↗

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.