Article
Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblasts.
Neurobiology of aging - 1 Feb 2011
Pensalfini Anna, Zampagni Mariagioia, Liguri Gianfranco, Becatti Matteo, Evangelisti Elisa, Fiorillo Claudia, Bagnoli Silvia, Cellini Elena, Nacmias Benedetta, Sorbi Sandro, Cecchi Cristina
Abstract excerpt
A growing body of evidence implicates low membrane cholesterol in the pathogenesis of Alzheimer's disease (AD). Here we show that Aβ42 soluble oligomers accumulate more slowly and in reduced amount at the plasma membranes of PS-1L392V and APPV717I fibroblasts from familial AD (FAD) patients enriched in cholesterol content than at the counterpart membranes. The Aβ42-induced production of reactive oxygen species...
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