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Article

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.

Journal of neuroscience research - 1 Apr 2010

Oda Akiko, Tamaoka Akira, Araki Wataru

Abstract excerpt

Oxidative stress is associated with beta-amyloid peptide (A beta) accumulation in the brains of Alzheimer's disease patients. A beta is generated upon the sequential proteolytic cleavage of transmembrane amyloid precursor protein (APP) by two membrane-bound proteases, beta-secretase (BACE1) and the gamma-secretase complex comprising presenilin 1 (PS1), nicastrin, APH-1 and PEN-2. Recent evidence suggests that...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19885829
DOI: 10.1002/jnr.22271

Genes

BACE1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.PMID 19885829Read ↗

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