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Article

Intracellular calcium signalling in Alzheimer’s disease

19 Nov 2009

Abstract excerpt

• Introduction • Dysregulation of Ca2+ homeostasis in AD - Aβ accumulation causes Ca2+ dyshomeostasis - Ca2+ dyshomeostasis increases Aβ production • Presenilins and Ca2+ homeostasis • Dysregulation of Ca2+ homeostasis in vivo • AD-mediated hyperactivity and synaptic network dysfunction • Neuronal hyperactivity: implications for humans • Plaque vicinity • Conclusions More than two decades ago, dysregulation of...

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PMID: 19929945
DOI: 10.1111/j.1582-4934.2009.00976.x

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