Article
African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.
Nature communications - 7 Apr 2026
Muriuki John Muthii, Mentzer Alexander J, Band Gavin, Chong Amanda Y, Macharia Alex W, Mogire Reagan M, Abuga Kelvin Mokaya, Mitchell Ruth, Gilchrist James J, Webb Emily L, Ndungu Francis M, Raffield Laura M, Ekunwe Lynette, Bentley Amy R, Sirima Sodiomon B, Madhi Shabir A, Hill Adrian V S, Prentice Andrew M, Bejon Philip, Hemani Gibran, Smith George Davey, Sandhu Manjinder S, Elliott Alison M, Williams Thomas N, Adeyemo Adebowale, Atkinson Sarah H
Abstract excerpt
Iron is essential for both humans and pathogens, yet its genetic regulation remains understudied in African populations. Here, we report genome-wide association studies of six iron-related biomarkers in 3928 children from five sites across Africa, with replication in 2868 African American adults and investigate associations with severe malaria and bacteremia. We identify previously unreported loci at genome-wide...
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