Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate

23 Aug 2012

Abstract excerpt

Hepatitis C virus (HCV) is present in the host with multiple variants generated by its error prone RNA-dependent RNA polymerase. Little is known about the initial viral diversification and the viral life cycle processes that influence diversity. We studied the diversification of HCV during acute infection in 17 plasma donors, with frequent sampling early in infection. To analyze these data, we developed a new...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to HIV Research and Treatment
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22927817
DOI: 10.1371/journal.ppat.1002881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation RatePMID 22927817Read ↗

Highly heterogeneous mutation rates in the hepatitis C virus genome.Semantic proximity Read ↗

Exceptional Heterogeneity in Viral Evolutionary Dynamics Characterises Chronic Hepatitis C Virus InfectionSemantic proximity Read ↗

Hepatitis C virus transmission bottlenecks analyzed by deep sequencing.Semantic proximity Read ↗

Extremely High Mutation Rate of HIV-1 In VivoSemantic proximity Read ↗

Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection.Semantic proximity Read ↗

Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification.Semantic proximity Read ↗

Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome SequencingSemantic proximity Read ↗

Mechanisms and Consequences of Genetic Variation in Hepatitis C Virus (HCV).Semantic proximity Read ↗

Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity.Semantic proximity Read ↗

High resolution evolutionary analysis of within-host hepatitis C virus infectionSemantic proximity Read ↗

Assessing <i>in vivo</i> mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virusSemantic proximity Read ↗

Integrating Phylodynamics and Epidemiology to Estimate Transmission Diversity in Viral EpidemicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.