Article
Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification.
Journal of virology - 1 Jan 2016
Li Hui, Stoddard Mark B, Wang Shuyi, Giorgi Elena E, Blair Lily M, Learn Gerald H, Hahn Beatrice H, Alter Harvey J, Busch Michael P, Fierer Daniel S, Ribeiro Ruy M, Perelson Alan S, Bhattacharya Tanmoy, Shaw George M
Abstract excerpt
UNLABELLED: Despite the recent development of highly effective anti-hepatitis C virus (HCV) drugs, the global burden of this pathogen remains immense. Control or eradication of HCV will likely require the broad application of antiviral drugs and development of an effective vaccine. A precise molecular identification of transmitted/founder (T/F) HCV genomes that lead to productive clinical infection could play a...
Topics
- Animals
- Cluster Analysis
- Genetic Variation
- Genome, Viral
- Genotype
- Genotyping Techniques
- Hepacivirus
- Hepatitis C
- Humans
- Liver Transplantation