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Article

Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection.

PLoS pathogens - 1 Sept 2011

Bull Rowena A, Luciani Fabio, McElroy Kerensa, Gaudieri Silvana, Pham Son T, Chopra Abha, Cameron Barbara, Maher Lisa, Dore Gregory J, White Peter A, Lloyd Andrew R

Abstract excerpt

Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and liver disease. The characterization of viral populations that successfully initiate infection, and also those that drive progression to chronicity is instrumental for understanding pathogenesis and vaccine design. A comprehensive and longitudinal analysis of the viral population was conducted in four subjects followed from very...

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Identifiers

PMID: 21912520
DOI: 10.1371/journal.ppat.1002243
PMCID: PMC3164670

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