Article

Assessing <i>in vivo</i> mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus

2020-10-02

Abstract excerpt

Like many viruses, Hepatitis C Virus (HCV) has a high nutation rate, which helps the virus adapt quickly, but mutations come with fitness costs. Fitness costs can be studied by different approaches, such as experimental or frequency-based approaches. The frequency-based approach is particularly useful to estimate in vivo fitness costs, but this approach works best with deep sequencing data from many hosts, are. I...

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Literature Corpus work: 28d25829-a555-54cc-aff0-2ce447e336c0
DOI: 10.1101/2020.10.01.323253

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