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Small-Molecule Klotho Enhancers As Novel Treatment Of Neurodegeneration

28 Aug 2012

Abstract excerpt

The majority of neurodegenerative diseases have an important age component, and thus, understanding the molecular changes that occur during normal aging of the brain is of utmost relevance. In search for the basis of the age-related cognitive decline found in humans, monkeys and rodents, we study the rhesus monkey. Surprisingly, there is no loss of neurons in aged monkey brains. However, we reported white matter...

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PMID: 22924505
DOI: 10.4155/fmc.12.134

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