Article

Knockout of the longevity gene Klotho perturbs aging- and Alzheimer’s disease-linked brain microRNAs and tRNA fragments

2023-09-12

Abstract excerpt

<h4>Introductory paragraph</h4> Overexpression of the longevity gene Klotho prolongs, while its knockout shortens lifespan and impairs cognition via altered fibroblast growth factor signaling that perturbs myelination and synapse formation; however, comprehensive analysis of Klotho’s knockout consequences on mammalian brain transcriptomics is lacking. Here, we report the altered levels under Klotho knockout of 10...

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Literature Corpus work: 62b04732-85bd-5885-a607-97f70150824e
DOI: 10.1101/2023.09.10.557032

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