Article

Longevity factor klotho and resistance to cognitive deficits in a transgenic mouse model and in individuals with Parkinson’s disease

2020-10-16

Abstract excerpt

<title>Abstract</title> <p>Aging is the primary risk factor for Parkinson’s disease (PD) and cognitive impairment from PD is a major and unmet biomedical challenge. Klotho, a pleiotropic protein, extends lifespan and enhances cognition. Whether longevity factors such as klotho can counteract PD-related mortality and deficits in mice or associate with resistance to PD in humans is unknown. Here we show that transg...

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Literature Corpus work: 5a2d1728-152d-5e13-bb7c-2891d01fe639
DOI: 10.21203/rs.3.rs-89525/v1

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