Article
Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2010
Chang Jeffrey S, Wiemels Joseph L, Chokkalingam Anand P, Metayer Catherine, Barcellos Lisa F, Hansen Helen M, Aldrich Melinda C, Guha Neela, Urayama Kevin Y, Scélo Ghislaine, Green Janet, May Suzanne L, Kiley Vincent A, Wiencke John K, Buffler Patricia A
Abstract excerpt
BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) has been hypothesized to have an infection- and immune-related etiology. The lack of immune priming in early childhood may result in abnormal immune responses to infections later in life and increase ALL risk. METHODS: The current analyses examined the association between childhood ALL and 208 single-nucleotide polymorphisms (SNP) of 29 adaptive immune...
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