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Article

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jul 2009

Wang Xinglong, Su Bo, Lee Hyoung-gon, Li Xinyi, Perry George, Smith Mark A, Zhu Xiongwei

Abstract excerpt

Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD) neurons. In this study, we explored the involvement of an abnormal mitochondrial dynamics by investigating the changes in the expression of mitochondrial fission and fusion proteins in AD brain and the potential cause and consequence of these changes in neuronal cells. We found that mitochondria were redistributed away from axons in the...

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Identifiers

PMID: 19605646
DOI: 10.1523/JNEUROSCI.1357-09.2009
PMCID: PMC2735241

Genes

OPA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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