Article
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
PLoS biology - 1 Dec 2018
Bardai Farah H, Ordonez Dalila G, Bailey Rachel M, Hamm Matthew, Lewis Jada, Feany Mel B
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the molecular connection between tau and Parkinson disease are unclear. Here, we investigate the interaction of LRRK and tau in Drosophila and mouse models of...
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