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Article

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell.

Biochimica et biophysica acta - 1 Feb 2014

Gan Xueqi, Huang Shengbin, Wu Long, Wang Yongfu, Hu Gang, Li Guangyue, Zhang Hongju, Yu Haiyang, Swerdlow Russell Howard, Chen John Xi, Yan Shirley ShiDu

Abstract excerpt

Mitochondrial dysfunction is an early pathological feature of Alzheimer's disease (AD). The underlying mechanisms and strategies to repair it remain unclear. Here, we demonstrate for the first time the direct consequences and potential mechanisms of mitochondrial functional defects associated with abnormal mitochondrial dynamics in AD. Using cytoplasmic hybrid (cybrid) neurons with incorporated platelet...

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Identifiers

PMID: 24252614
DOI: 10.1016/j.bbadis.2013.11.009
PMCID: PMC3991235

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