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Article

DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants.

Scientific reports - 9 May 2018

Scholtes Charlotte, Bellemin Stéphanie, Martin Edwige, Carre-Pierrat Maïté, Mollereau Bertrand, Gieseler Kathrin, Walter Ludivine

Abstract excerpt

Mitochondria are double-membrane subcellular organelles with highly conserved metabolic functions including ATP production. Mitochondria shapes change continually through the combined actions of fission and fusion events rendering mitochondrial network very dynamic. Mitochondria are largely implicated in pathologies and mitochondrial dynamics is often disrupted upon muscle degeneration in various models....

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Identifiers

PMID: 29743663
DOI: 10.1038/s41598-018-25727-8
PMCID: PMC5943356

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