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A partial reduction of Drp1 enhances mitophagy, autophagy, mitochondrial biogenesis, dendritic spines and synaptic activity in a transgenic Tau mouse model of Alzheimer disease

2021-10-09

Abstract excerpt

The purpose of our study is to understand the impact of a partial dynamin-related protein 1 (Drp1) on cognitive behavior, mitophagy/autophagy, mitochondrial and synaptic activities in transgenic Tau mice in Alzheimer’s disease (AD). Our lab reported increased levels of Aβ and P-Tau, and abnormal interactions between Aβ and Drp1, P-Tau and Drp1 induced increased mitochondrial fragmentation and reduced fusion and sy...

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Literature Corpus work
ba5f2862-04b7-5e0e-b419-2e2e1b46e046
DOI
10.1101/2021.10.07.463521
Open publication

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A partial reduction of Drp1 enhances mitophagy, autophagy, mitochondrial biogenesis, dendritic spines and synaptic activity in a transgenic Tau mouse model of Alzheimer diseaseDOI 10.1101/2021.10.07.463521
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