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Article

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.

Brain research reviews - 24 Jun 2011

Reddy P Hemachandra, Reddy Tejaswini P, Manczak Maria, Calkins Marcus J, Shirendeb Ulziibat, Mao Peizhong

Abstract excerpt

The purpose of this article is to review the recent developments of abnormal mitochondrial dynamics, mitochondrial fragmentation, and neuronal damage in neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. The GTPase family of proteins, including fission proteins, dynamin related protein 1 (Drp1), mitochondrial fission 1 (Fis1), and fusion proteins...

Topics

Animals
Cell Respiration
Dynamins
GTP Phosphohydrolases
Humans
Microtubule-Associated Proteins
Mitochondria
Mitochondrial Diseases
Mitochondrial Proteins
Models, Animal
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurodegenerative Diseases

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Identifiers

PMID: 21145355
DOI: 10.1016/j.brainresrev.2010.11.004
PMCID: PMC3061980

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