Article

Imbalanced mitochondrial dynamics in human and mouse PD brains

2025-01-28

Abstract excerpt

Mitochondrial dysfunction is a major pathogenic mechanism in Parkinson’s disease (PD). Emerging studies have shown that dysregulation in mitochondrial dynamics (fission/fusion/movement) has a major negative impact on mitochondria - both morphologically and functionally. Partial genetic deletion and pharmacological inhibition of the mitochondrial fission dynamin-related protein 1 (Drp1) have been demonstrated to be...

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Literature Corpus work: f99f40e9-d96e-5d7a-a754-b208fff10a03
DOI: 10.1101/2025.01.27.635175

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