Article
Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation.
Molecular and cellular biology - 1 Nov 2000
Yang H, Jiang W, Gentry M, Hallberg R L
Abstract excerpt
CDC55 encodes a Saccharomyces cerevisiae protein phosphatase 2A (PP2A) regulatory subunit. cdc55-null cells growing at low temperature exhibit a failure of cytokinesis and produce abnormally elongated buds, but cdc55-null cells producing the cyclin-dependent kinase Cdc28-Y19F, which is unable to be inhibited by Y19 phosphorylation, show a loss of the abnormal morphology. Furthermore, cdc55-null cells exhibit a...
Topics
- Alkaline Phosphatase
- Antineoplastic Agents
- Blotting, Northern
- Blotting, Western
- Cell Cycle Proteins
- Cell Division
- Electrophoresis, Polyacrylamide Gel
- Fungal Proteins
- G2 Phase
- Gene Deletion
- Kinetics
- Mitosis
- Nocodazole
- Phenotype