Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast.

The EMBO journal - 1 Mar 2001

Mizunuma M, Hirata D, Miyaoka R, Miyakawa T

Abstract excerpt

The Ca2+-activated pathways of Saccharomyces cerevisiae induce a delay in the onset of mitosis through the activation of Swe1, a negative regulatory kinase that inhibits the Cdc28-Clb complex. Calcineurin and Mpk1 activate Swe1 at the transcriptional and post-translational level, respectively, and both pathways are essential for the cell cycle delay. Our genetic screening identified the MCK1 gene, which encodes a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Calcineurin
Share to F-Box Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G2 Phase

Share to Glycogen Synthase Kinase 3

Share to Peptide Synthases

Share to SKP Cullin F-Box Protein Ligases

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 11230131
DOI: 10.1093/emboj/20.5.1074
PMCID: PMC145470

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast.PMID 11230131Read ↗

The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division.Semantic proximity Read ↗

Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.Semantic proximity Read ↗

Clb2 and the APC/C(Cdh1) regulate Swe1 stability.Semantic proximity Read ↗

Nucleocytoplasmic trafficking of G2/M regulators in yeast.Semantic proximity Read ↗

Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast.Semantic proximity Read ↗

Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation.Semantic proximity Read ↗

The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions.Semantic proximity Read ↗

The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation.Semantic proximity Read ↗

Cdk1 and SUMO regulate Swe1 stability.Semantic proximity Read ↗

Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis.Semantic proximity Read ↗

Cdc5 interacts with the Wee1 kinase in budding yeast.Semantic proximity Read ↗

Determinants of Swe1p degradation in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.