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Article

Mih1/Cdc25 is negatively regulated by Pkc1 in Saccharomyces cerevisiae.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2013

Yano Kouitiro, Uesono Yukifumi, Yoshida Satoshi, Kikuchi Akihiko, Kashiwazaki Jun, Mabuchi Issei, Kikuchi Yoshiko

Abstract excerpt

Mitotic cyclin-dependent kinase (CDK) is activated by Cdc25 phosphatase through dephosphorylation at the Wee1-mediated phosphorylation site. In Saccharomyces cerevisiae, regulation of Mih1 (Cdc25 homologue) remains unclear because inactivation/degradation of Swe1 (Wee1 homologue) is the main trigger for G2/M transition. By deleting all mitotic cyclins except Clb2, a strain was created where Mih1 became essential...

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PMID: 23510481
DOI: 10.1111/gtc.12047

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SDS

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Mih1/Cdc25 is negatively regulated by Pkc1 in Saccharomyces cerevisiae.PMID 23510481Read ↗

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