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Article

Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector.

Genetics - 1 Dec 2007

Kankel Mark W, Hurlbut Gregory D, Upadhyay Geeta, Yajnik Vijay, Yedvobnick Barry, Artavanis-Tsakonas Spyros

Abstract excerpt

Notch signaling regulates multiple developmental processes and is implicated in various human diseases. Through use of the Notch transcriptional co-activator mastermind, we conducted a screen for Notch signal modifiers using the Exelixis collection of insertional mutations, which affects approximately 50% of the Drosophila genome, recovering 160 genes never before associated with Notch, extending the previous...

Topics

Animals
Drosophila Proteins
Gene Regulatory Networks
Genes, Insect
Genome, Insect
Mutation
Nuclear Proteins
Receptors, Notch
Signal Transduction
Wnt Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18073442
DOI: 10.1534/genetics.107.080994
PMCID: PMC2219471

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