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Characterization of a new mastermind allele identified from somatic mosaic screen.

Cells & development - 1 Mar 2021

Chang Xinyue, Zhang Fengchao, Li Haomiao, Mo Dongqing, Shen Jie, Zhang Junzheng

Abstract excerpt

The Notch signaling pathway is highly conserved and regulates various fundamental development events. Activation of Notch signaling relies on production of the Notch intracellular domain (NICD), which assembles a transcription factor complex to turn on down-stream targets expression. The mastermind (mam) gene encodes an essential co-activator that permits NICD activity in the cell nucleus. During a somatic mosaic...

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PMID: 33993981
DOI: 10.1016/j.cdev.2021.203664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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