Article
Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population.
Applied immunohistochemistry & molecular morphology : AIMM - 1 May 2013
Chaar Ines, Amara Sameh, Khiari Mariem, Ounissi Donia, Dhraif Monia, Ben Hamida Abd E M, Gharbi Lassad, Mzabi Sabeh, Bouraoui Saadia
Abstract excerpt
BACKGROUND: The prevalence of p53 mutations in colorectal cancer could reach 90%. The most important regulator of this protein that was identified originally was the Murine Double Minute2 (MDM2) oncoprotein, by which the levels of p53 were fixed through an autoregulatory feedback loop. In cancer cases, the overexpression of MDM2 deregulates this feedback, and the signaling pathway between MDM2 and p53 is blocked....
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