Copy number variation and incomplete linkage disequilibrium interfere with the HCP5 genotyping assay for abacavir hypersensitivity.

doi:10.1089/gtmb.2012.0115

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Article

Copy number variation and incomplete linkage disequilibrium interfere with the HCP5 genotyping assay for abacavir hypersensitivity.

Genetic testing and molecular biomarkers - 1 Sept 2012

Melis Roberta, Lewis Tracy, Millson Alison, Lyon Elaine, McMillin Gwendolyn A, Slev Patricia R, Swensen Jeffrey

Abstract excerpt

Carriers of HLA-B*57:01 are at risk for Abacavir hypersensitivity reaction (ABC-HSR). In Caucasians, a SNP (rs2395029) in the HCP5 gene is reported to be in linkage disequilibrium (LD) with HLA-B*57:01. Genotyping the HCP5 SNP has increasingly been adopted as a simple method to screen for susceptibility to ABC-HSR. We genotyped both the HCP5 SNP and HLA-B*57:01 in a set of 1888 samples and found a good...

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PMID: 22913531
DOI: 10.1089/gtmb.2012.0115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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