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Article

HCP5 rs2395029 is a rapid and inexpensive alternative to HLA-B*57:01 genotyping to predict abacavir hypersensitivity reaction in Spain.

Pharmacogenetics and genomics - 1 Apr 2021

Zubiaur Pablo, Saiz-Rodríguez Miriam, Villapalos-García Gonzalo, Navares-Gómez Marcos, Koller Dora, Abad-Santos Francisco

Abstract excerpt

Abacavir (ABC) is an HIV nucleotide-analogue reverse transcriptase inhibitor that can produce a severe hypersensitivity reaction (ABC-HSR) in about 5% of the patients. The HLA-B*57:01 allele is associated with the development of ABC-HSR. Therefore, HLA-B*57:01 genotyping is required prior to the prescription of ABC. The technique routinely used in our laboratory is the sequence-specific oligonucleotide probes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33044391
DOI: 10.1097/FPC.0000000000000421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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