Article
Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations.
Pharmacogenomics - 1 Mar 2004
Hughes Arlene R, Mosteller Michael, Bansal Aruna T, Davies Kirstie, Haneline Stephen A, Lai Eric H, Nangle Keith, Scott Trevor, Spreen William R, Warren Liling L, Roses Allen D
Abstract excerpt
Abacavir is an effective antiretroviral drug used to treat HIV-1 infection. Approximately 5% of patients treated with abacavir develop a hypersensitivity reaction that requires discontinuation of the drug. In an initial pharmacogenetic study conducted in a predominantly White male population, multiple markers in the human leukocyte antigen (HLA)-B chromosomal region were associated with hypersensitivity to...
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