Article
Association of the genetic marker for abacavir hypersensitivity HLA-B*5701 with HCP5 rs2395029 in Mexican Mestizos.
Pharmacogenomics - 1 Jun 2011
Sanchez-Giron Francisco, Villegas-Torres Beatriz, Jaramillo-Villafuerte Karla, Silva-Zolezzi Irma, Fernandez-Lopez Juan Carlos, Jimenez-Sanchez Gerardo, Carnevale Alessandra
Abstract excerpt
UNLABELLED: Prospective screening for HLA-B*5701 decreases or abolishes abacavir hypersensitivity reaction. In Caucasians, the HLA complex protein 5 gene (HCP5) rs2395029(G) allele is in complete linkage disequilibrium (LD) with HLA-B*5701 (r(2) = 1). AIM: To assess the frequency of HLA-B*5701 and its LD with HCP5 rs2395029(G) allele, to extend our knowledge of genetic variants that are of critical relevance for...
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