Rapid HCP5 single-nucleotide polymorphism genotyping: a simple allele-specific PCR method for prediction of hypersensitivity reaction to Abacavir.

doi:10.1016/j.cca.2011.04.010

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Article

Rapid HCP5 single-nucleotide polymorphism genotyping: a simple allele-specific PCR method for prediction of hypersensitivity reaction to Abacavir.

Clinica chimica acta; international journal of clinical chemistry - 15 Jul 2011

Galván Cristian A, Elbarcha Osvaldo C, Fernández Eduardo J, Beltramo Dante M, Soria Néstor Walter

Abstract excerpt

BACKGROUND: The most important factor limiting the success of an antiretroviral therapy is toxicity. The HLA-B*5701 allele is predictive of hypersensitivity reaction to Abacavir, and this gene is in a perfect linkage disequilibrium with the rs2395029 SNP present in the HCP5 gene. METHODS: Genomic DNA was extracted from blood obtained from 201 unrelated healthy Argentinean volunteers. The DNA was subjected to an...

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PMID: 21514285
DOI: 10.1016/j.cca.2011.04.010

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