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Article

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir.

Lancet (London, England) - 30 Mar 2002

Hetherington Seth, Hughes Arlene R, Mosteller Michael, Shortino Denise, Baker Katherine L, Spreen William, Lai Eric, Davies Kirstie, Handley Abigail, Dow David J, Fling Mary E, Stocum Michael, Bowman Clive, Thurmond Linda M, Roses Allen D

Abstract excerpt

Hypersensitivity to abacavir affects about 4% of patients who receive the drug for HIV-1 infection. We did a retrospective, case-control study to identify multiple markers in the vicinity of HLA-B associated with hypersensitivity reactions. HLA-B57 was present in 39 (46%) of 84 patients versus four (4%) of 113 controls (p<0 small middle dot0001). However, because of low numbers of women and other ethnic groups...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11943262
DOI: 10.1016/S0140-6736(02)08158-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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