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Article

The path to chemotaxis and transcription is smoothened.

Science signaling - 21 Aug 2012

Lin Chuwen, Nozawa Yoko Inès, Chuang Pao-Tien

Abstract excerpt

The Hedgehog (Hh) family of secreted proteins governs the development of numerous tissues by regulating the activity of the Gli family of transcription factors. Emerging evidence shows that Hh also functions as a chemoattractant in several processes through a noncanonical pathway independent of Gli-mediated transcription. How Hh-responsive cells execute transcriptional versus chemotactic responses is a key issue....

Read the complete abstract on PubMed

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Share to Chemotaxis
Share to Cilia
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Receptors, G-Protein-Coupled

Share to Smoothened Receptor

Share to Transcription, Genetic

Share to Zinc Finger Protein GLI1

Source

Identifiers

PMID: 22912492
DOI: 10.1126/scisignal.2003423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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