Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Validation of tacrolimus equation to predict troughs using genetic and clinical factors.

Pharmacogenomics - 1 Jul 2012

Passey Chaitali, Birnbaum Angela K, Brundage Richard C, Schladt David P, Oetting William S, Leduc Robert E, Israni Ajay K, Guan Weihua, Matas Arthur J, Jacobson Pamala A

Abstract excerpt

AIM: Tacrolimus is an immunosuppressant used in transplantation. This article reports the validation of the authors' recently developed genetics-based tacrolimus equation that predicts troughs. METHODS: Validation was performed in an independent cohort of 795 kidney transplant recipients receiving tacrolimus. The performance of the equation to predict initial troughs was assessed by calculating the bias and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Pharmacological
Share to Clinical Trials as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Dose-Response Relationship, Drug

Share to Genotype

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Tacrolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 22909204
DOI: 10.2217/pgs.12.98
PMCID: PMC3579500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validation of tacrolimus equation to predict troughs using genetic and clinical factors.PMID 22909204Read ↗

Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors in Kidney Transplant Recipients of European Ancestry.Semantic proximity Read ↗

Assessing the Utility of a Genotype-Guided Tacrolimus Equation in African American Kidney Transplant Recipients: A Single Institution Retrospective Study.Semantic proximity Read ↗

Dosing equation for tacrolimus using genetic variants and clinical factors.Semantic proximity Read ↗

Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients.Semantic proximity Read ↗

An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients.Semantic proximity Read ↗

A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients.Semantic proximity Read ↗

Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling.Semantic proximity Read ↗

Genotype-Guided Model for Prediction of Tacrolimus Initial Dosing After Lung Transplantation.Semantic proximity Read ↗

Genotype Informed Bayesian Dosing of Tacrolimus in Paediatric Solid Organ Transplant IndividualsSemantic proximity Read ↗

A prospective controlled, randomized clinical trial of kidney transplant recipients developed personalized tacrolimus dosing using model-based Bayesian Prediction.Semantic proximity Read ↗

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.Semantic proximity Read ↗

Evaluating tacrolimus pharmacokinetic models in adult renal transplant recipients with different CYP3A5 genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.