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Article

Genotype Informed Bayesian Dosing of Tacrolimus in Paediatric Solid Organ Transplant Individuals

2023-11-14

Abstract excerpt

Tacrolimus, a calcineurin inhibitor, is an effective immunosuppressant for solid organ transplants (SOT). However, its narrow therapeutic index and high variability in pharmacokinetics can lead to inefficacy, toxicities, and suboptimal outcomes. Genotyping for CYP3A5 gene prior to SOT can identify individuals at risk of high or low tacrolimus levels and guide first-dose dosing. Genotype-guided Bayesian dosing uses...

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Literature Corpus work
754c72db-26d9-5635-a546-d78e7347e22d
DOI
10.22541/au.169996506.63522482/v1
Open publication

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Genotype Informed Bayesian Dosing of Tacrolimus in Paediatric Solid Organ Transplant IndividualsDOI 10.22541/au.169996506.63522482/v1
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