Article
An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients.
Transplantation - 1 Mar 2022
Min Sandar, Papaz Tanya, Lambert A Nicole, Allen Upton, Birk Patricia, Blydt-Hansen Tom, Foster Bethany J, Grasemann Hartmut, Hamiwka Lorraine, Litalien Catherine, Ng Vicky, Berka Noureddine, Campbell Patricia, Daniel Claude, Saw Chee Loong, Tinckam Kathryn, Urschel Simon, Van Driest Sara L, Parekh Rulan, Mital Seema
Abstract excerpt
BACKGROUND: There are challenges in achieving and maintaining therapeutic tacrolimus levels after solid organ transplantation (SOT). The purpose of this genome-wide association study was to generate an integrated clinical and genetic prediction model for tacrolimus levels in pediatric SOT. METHODS: In a multicenter prospective observational cohort study (2015-2018), children <18 years old at their first SOT...
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