Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients.

Pharmacogenomics - 1 Feb 2018

Oetting William S, Wu Baolin, Schladt David P, Guan Weihua, Remmel Rory P, Dorr Casey, Mannon Roslyn B, Matas Arthur J, Israni Ajay K, Jacobson Pamala A

Abstract excerpt

AIM: Multiple genetic variants have been associated with variation in tacrolimus (TAC) trough concentrations. Unfortunately, additional studies do not confirm these associations, leading one to question if a reported association is accurate and reliable. We attempted to validate 44 published variants associated with TAC trough concentrations. MATERIALS & METHODS: Genotypes of the variants in our cohort of 1923...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Immunocompromised Host

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Tacrolimus

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 29318894
DOI: 10.2217/pgs-2017-0187
PMCID: PMC6021962

Genes

CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients.PMID 29318894Read ↗

Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium.Semantic proximity Read ↗

Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients.Semantic proximity Read ↗

Multigene predictors of tacrolimus exposure in kidney transplant recipients.Semantic proximity Read ↗

A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.Semantic proximity Read ↗

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.Semantic proximity Read ↗

The role of single nucleotide polymorphisms of CYP3A and ABCB1 on tacrolimus predose concentration in kidney transplant recipients.Semantic proximity Read ↗

Genotype-guided tacrolimus dosing: The role of CYP3A5 polymorphisms in optimising kidney transplant immunosuppression in BhutanSemantic proximity Read ↗

Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors in Kidney Transplant Recipients of European Ancestry.Semantic proximity Read ↗

Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.Semantic proximity Read ↗

Validation of tacrolimus equation to predict troughs using genetic and clinical factors.Semantic proximity Read ↗

Clinical impact of the CYP3A5 6986A>G allelic variant on kidney transplantation outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.