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Article

Engineering of large deletions and duplications in vivo.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Lefebvre Louis

Abstract excerpt

Gene targeting in embryonic stem (ES) cells coupled with the site-specific Cre/loxP recombination system offers unique opportunities to identify and analyze the roles of cis-acting sequences in the regulation of imprinted gene expression. Although several different approaches have been described to engineer large chromosomal rearrangements in ES cells, these strategies can be labor-intensive and often require...

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PMID: 22907494
DOI: 10.1007/978-1-62703-011-3_8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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