Article
Chromosomal deletion complexes in mice by radiation of embryonic stem cells.
Nature genetics - 1 Mar 1997
You Y, Bergstrom R, Klemm M, Lederman B, Nelson H, Ticknor C, Jaenisch R, Schimenti J
Abstract excerpt
Chromosomal deletions ("deficiencies') are powerful tools in the genetic analysis of complex genomes. They have been exploited extensively in Drosophila melanogaster, an organism in which deficiencies can be efficiently induced and selected. Spontaneous deletions in humans have facilitated the dissection of phenotypes in contiguous gene syndromes and led to the positional cloning of critical genes. In mice,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.