Article
Chromosomal deletion complexes in mice by radiation of embryonic stem cells.
Nature genetics - 1 Mar 1997
You Y, Bergstrom R, Klemm M, Lederman B, Nelson H, Ticknor C, Jaenisch R, Schimenti J
Abstract excerpt
Chromosomal deletions ("deficiencies') are powerful tools in the genetic analysis of complex genomes. They have been exploited extensively in Drosophila melanogaster, an organism in which deficiencies can be efficiently induced and selected. Spontaneous deletions in humans have facilitated the di...
Topics
- Animals
- Cell Survival
- Chromosome Deletion
- Chromosome Mapping
- Crosses, Genetic
- Dose-Response Relationship, Radiation
- Drosophila melanogaster
- Embryo, Mammalian
- Embryo, Nonmammalian
- Female
- Genetic Markers
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred Strains
- Phenotype
- Polymorphism, Genetic