Article
A mixed-model approach for genome-wide association studies of correlated traits in structured populations.
Nature genetics - 1 Sept 2012
Korte Arthur, Vilhjálmsson Bjarni J, Segura Vincent, Platt Alexander, Long Quan, Nordborg Magnus
Abstract excerpt
Genome-wide association studies (GWAS) are a standard approach for studying the genetics of natural variation. A major concern in GWAS is the need to account for the complicated dependence structure of the data, both between loci as well as between individuals. Mixed models have emerged as a general and flexible approach for correcting for population structure in GWAS. Here, we extend this linear mixed-model...
Topics
- Arabidopsis
- Cluster Analysis
- Cohort Studies
- Computer Simulation
- Finland
- Flowers
- Gene-Environment Interaction
- Genetics, Population
- Genome, Plant
- Genome-Wide Association Study
- Humans