Article
A unified mixed-model method for association mapping that accounts for multiple levels of relatedness.
Nature genetics - 1 Feb 2006
Yu Jianming, Pressoir Gael, Briggs William H, Vroh Bi Irie, Yamasaki Masanori, Doebley John F, McMullen Michael D, Gaut Brandon S, Nielsen Dahlia M, Holland James B, Kresovich Stephen, Buckler Edward S
Abstract excerpt
As population structure can result in spurious associations, it has constrained the use of association studies in human and plant genetics. Association mapping, however, holds great promise if true signals of functional association can be separated from the vast number of false signals generated by population structure. We have developed a unified mixed-model approach to account for multiple levels of relatedness...
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