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Article

A Lasso multi-marker mixed model for association mapping with population structure correction.

Bioinformatics (Oxford, England) - 15 Jan 2013

Rakitsch Barbara, Lippert Christoph, Stegle Oliver, Borgwardt Karsten

Abstract excerpt

MOTIVATION: Exploring the genetic basis of heritable traits remains one of the central challenges in biomedical research. In traits with simple Mendelian architectures, single polymorphic loci explain a significant fraction of the phenotypic variability. However, many traits of interest seem to be subject to multifactorial control by groups of genetic loci. Accurate detection of such multivariate associations is...

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PMID: 23175758
DOI: 10.1093/bioinformatics/bts669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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