Article

Fast and flexible linear mixed models for genome-wide genetics

2018-07-23

Abstract excerpt

Linear mixed effect models are powerful tools used to account for population structure in genome-wide association studies (GWASs) and estimate the genetic architecture of complex traits. However, fully-specified models are computationally demanding and common simplifications often lead to reduced power or biased inference. We describe Grid-LMM ( https://github.com/deruncie/GridLMM ), an extendable algorithm for r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59d0a6c2-1960-57a9-aac7-a21034c2da77
DOI: 10.1101/373902

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fast and flexible linear mixed models for genome-wide geneticsDOI 10.1101/373902Read

LiMMBo: a simple, scalable approach for linear mixed models in high-dimensional genetic association studiesSemantic proximity Read

Efficient multivariate linear mixed model algorithms for genome-wide association studies.Semantic proximity Read

Ludicrous Speed Linear Mixed Models for Genome-Wide Association StudiesSemantic proximity Read

A generalized linear mixed model association tool for biobank-scale data.Semantic proximity Read

lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R.Semantic proximity Read

OmiGA: A Toolkit for Ultra-efficient Molecular Trait Analysis in Complex PopulationsSemantic proximity Read

An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations.Semantic proximity Read

A resource-efficient tool for mixed model association analysis of large-scale data.Semantic proximity Read

OmiGA: A Toolkit for Ultra-efficient Molecular Trait Analysis in Complex PopulationsSemantic proximity Read

Genome-wide efficient mixed-model analysis for association studies.Semantic proximity Read

A fast and powerful linear mixed model approach for genotype-environment interaction tests in large-scale GWAS.Semantic proximity Read

OmiGA for ultra-efficient molecular quantitative trait loci mapping.Semantic proximity Read